There are 5 difficulty levels to choose from. Difficulty levels affect various mechanics, and can be applied to both regular games and Challenge modes.
| Difficulty | Danger level and Enemy count | Enemy Accuracy | Other |
|---|---|---|---|
| Easy | Reduced | Enemies have half cover, Enemies deal 60% of normal damage | |
| Medium | Normal | ||
| Hard | Increased | ||
| Ultraviolence | Further Increased | +10% | |
| Nightmare! | Max | +10% | Nightmare respawn, +50% ammo |
| Apocalypse! | Max+1 | +10% | Nightmare respawn, +50% ammo, +50% Enemy Health |
| Inferno! | Max+2 | +10% | +50% ammo, +50% enemy health, regular enemies get exalted buffs |
The first three difficulty levels are always available.
Access to Ultraviolence Nightmare! and Apocalypse! are permanently unlocked by reaching an appropriate Rank.
Inferno! is unlocked by beating a special boss in Purgatory.
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